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March 1986

Pyoderma Gangrenosum Involving the Head and Neck

Author Affiliations

From the Dermatology Service, San Francisco Veterans Administration Medical Center, and the Department of Dermatology, University of California at San Francisco. Dr Snyder is now with the University of Miami School of Medicine and is also in private practice.

Arch Dermatol. 1986;122(3):295-302. doi:10.1001/archderm.1986.01660150073019

† In six patients with pyoderma gangrenosum, the head and neck region was a major site of ulcerative skin disease. In two patients, the disease was limited to this anatomic site. Corticosteroids were effective therapy in five cases. In one case, occurring in association with ulcerative colitis, total proctocolectomy was required to control ulcerative scalp disease. Detailed histologic examination of a primary lesion in one case with 0.5-μm sections demonstrated morphologic evidence of mast cell activation, suggesting that mast cells may contribute to the pathogenesis of the inflammatory process in pyoderma gangrenosum.

(Arch Dermatol 1986;122:295-302)

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