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April 1986

Successful Treatment of Generalized Discoid Skin Lesions With Azathioprine

Author Affiliations

The Skin Hospital George Road Edgbaston Birmingham B15 1RP, England

Arch Dermatol. 1986;122(4):376-377. doi:10.1001/archderm.1986.01660160026007

To the Editor.—  I read the article in the October 1985 issue of the Archives on the successful treatment of generalized discoid skin lesions with azathioprine sodium with interest.My experience with one patient who suffered severely from cutaneous lupus erythematosus lesions principally affecting the forearms, hands, legs, and feet, and, on occasion, involving sun-exposed areas of the face and upper chest, corresponds with that of the above-reported case with respect to outcome of treatment.

Report of a Case.—  A woman, born in 1920, developed cutaneous lupus erythematosus in 1970 and showed a poor response to treatment with 0.05% clobetasol.Since 1976, the patient also received systemic steroids continuously (prednisolone, 12.5 to 40 mg daily) with limited improvement in her condition despite sequential additions of other modes of treatment, which included isoniazid (100 mg daily), dapsone (100 mg daily), cyclophosphamide (50 mg daily), and chloroquine sulfate (100 to 200 mg