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April 1986

Erythrokeratodermia Variabilis Treated With Isotretinoin: A Clinical, Histologic, and Ultrastructural Study

Author Affiliations

From the Department of Dermatology, University of Minnesota, Minneapolis. Dr Rappaport is now in private practice, Norwalk, Conn; Dr Goldes is with Malcolm Grow Medical Center, Andrews Air Force Base, Camp Springs, Md; and Dr Goltz is with the University of California at San Diego Medical Center.

Arch Dermatol. 1986;122(4):441-445. doi:10.1001/archderm.1986.01660160097026

• A 30-year-old woman with erythrokeratodermia variabilis was treated with oral isotretinoin for four months. Clinical and light and electron microscopic observations were made before and after treatment. A characteristic electron microscopic feature was subnormal numbers of keratinosomes within the stratum granulosum of hyperkeratotic plaques. Isotretinoin therapy resulted in almost complete clinical clearing of these plaques and restoration of normal numbers of epidermal keratinosomes. In addition, distinctive dyskeratotic cells containing clumped tonofilaments were observed within the stratum granulosum by electron microscopy. These cells persisted after retinoid treatment.

(Arch Dermatol 1986;122:441-445)

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