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April 1986

Histiocytosis X: Flow Cytometric DNA-Content and Immunohistochemical and Ultrastructural Analysis

Author Affiliations

From the Departments of Dermatology (Drs Goldberg, Caro, and Zugerman), Oncology (Dr Rosen), and Pathology (Drs Bauer, Marder, Rao, and Variakojis), Northwestern University Medical School, Chicago.

Arch Dermatol. 1986;122(4):446-450. doi:10.1001/archderm.1986.01660160102027

• A 76-year-old man developed a generalized orangered nodular eruption associated with constitutional symptoms. A biopsy specimen of a nodule revealed an extensive infiltration of histiocytes with relatively abundant cytoplasm and folded nuclei. Electron microscopy showed Langerhans' cell granules, which confirmed the diagnosis of histiocytosis X. Results of immunohistochemical studies revealed a pattern of antigen expression usually found in histiocytosis X, including la, T6, and S100. Analysis of the DNA content of the cells with flow cytometry revealed an aneuploid peak. The patient responded partially to topical mechlorethamine hydrochloride therapy.

(Arch Dermatol 1986;122:446-450)