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May 1986

Pyoderma Gangrenosum in a Patient With HTLV-III Antibody

Author Affiliations

Department of Dermatology Dartmouth-Hitchcock Medical Center Hanover, NH 03756; Dover, NH

Arch Dermatol. 1986;122(5):508-509. doi:10.1001/archderm.1986.01660170032014

To the Editor.—  Pyoderma gangrenosum (PG) is an uncommon cutaneous ulcerative disease of unknown causes.1 Human T-cell lymphotropic virus type III (HTLV-III) antibody has been isolated in individuals with acquired immunodeficiency syndrome (AIDS) or at risk for AIDS.2 Both conditions have been associated with quantitative and qualitative abnormalities in humoral and cell-mediated immunity. We herein report a case in which the two conditions coexist.

Report of a Case.—  A 23-year-old homosexual man was examined at Dartmouth-Hitchcock Medical Center, Hanover, NH, in March 1985 for a six-year history of recurrent episodes of bilateral lower-extremity ulcers. The lesions have begun as inflammatory nodules or pustules, which rapidly enlarge and ulcerate. The tender ulcers have violaceous, undermined, raised borders with beefy exudative bases. The lesions are slow to heal, granulating over several months. Over the years, the patient has been treated with a variety of agents, including systemic and topical antibiotics,

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