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May 1986

A Case of Xeroderma Pigmentosum Group F With Late Onset of Clinical Symptoms

Author Affiliations

Department of Dermatology Department of Experimental Radiology Faculty of Medicine; Radiation Biology Center; Department of Experimental Radiology Faculty of Medicine; Department of Dermatology Faculty of Medicine Kyoto University Shogoin, Sakyo-ku Kyoto 606, Japan; Department of Dermatology Osaka Red Cross Hospital Fudegasaki-cho 5-53, Ten-nouji-ku Osaka 543, Japan

Arch Dermatol. 1986;122(5):510-511. doi:10.1001/archderm.1986.01660170034016

To the Editor.—  Xeroderma pigmentosum (XP) is a genetic disease characterized by photosensitivity and early appearance of skin cancers. To date, nine genetic complementation groups from A to I have been identified.1-3 The complementation group F was first reported by Arase et al in 1979,4 and three more cases have been identified in Japan.1 Its characteristic features are mild clinical manifestations and late onset, despite apparently low DNA repair capacities in the cells cultured from the patients. In this letter, we describe another case of XP F that developed in a 49-year-old woman, who had not noticed photosensitivity until she was examined.

Report of a Case.—  A 49-year-old woman was sent to the outpatient clinic of the dermatology department by her family physician because of a generalized eruption. Amoxicillin trihydrate was administered in August 1981 for a suppurating brown nodule, measuring 0.8 × 0.6 cm on the

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