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June 1986

Darier's Disease Complicated by Trichophyton rubrum Infection

Author Affiliations

Department of Dermatology Royal Free Hospital London, England NW3 2QG

Arch Dermatol. 1986;122(6):623. doi:10.1001/archderm.1986.01660180023002

To the Editor.—  We were interested to read the article by Wheeland et al1 in the July 1985 issue of the Archives, which described Darier's disease complicated by Trichophyton tonsurans infection. We, too, have encountered chronic dermatophyte infection complicating Darier's disease in two of 17 family members with Darier's disease.2 They were a brother and sister with the typical features of Darier's disease and an associated dyskeratosis of the palms and soles in the form of keratoderma. Both developed a chronic Trichophyton rubrum infection of the palms, soles, and nails. The fungus infection remained refractory to prolonged courses of oral griseofulvin.Patients with Darier's disease are known to be susceptible to viral and bacterial infections of the skin, and this has been attributed to immunodeficiency.3 We share the belief of Wheeland and colleagues that the fungal infection encountered in Darier's disease is probably related to the dyskera