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June 1986

Effect of Topical Application of Glycine and Proline on Recalcitrant Leg Ulcers of Prolidase Deficiency

Author Affiliations

Department of Dermatology Kochi Medical School Kochi, 781-51 Nankoku-shi, Japan

Arch Dermatol. 1986;122(6):626-627. doi:10.1001/archderm.1986.01660180026006

To the Editor.—  The most important dermatologic problem of prolidase deficiency1 is chronic recurrent leg ulcers that are recalcitrant in healing. We used 5% glycine-5% proline ointment on leg ulcers with excellent results.

Report of a Case.—  The patient, now a 22-year-old woman, is the same patient as described previously.1 She had never been free of recalcitrant leg ulcers despite various conventional therapies including topical application of antibiotics (gentamicin sulfate, colistin sulfate, polymyxin B sulfate, etc), leg bath in 0.01% potassium permanganate solution, oral administration of zinc sulfate (180 mg daily), and/or ascorbic acid (3 g daily). Oral L-proline (1 g daily) was also tried for two months with no apparent benefit. We decided to use topical proline and then a combination of topical proline and glycine on her leg ulcers. L-proline and/or L-glycine ground with a mortar and pestle was mixed in liquid paraffin (30 g) and