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June 1986

The Association of HLA and Immune Responses to Bovine Collagen Implants

Author Affiliations

From the Departments of Dermatology (Drs Vanderveen, Grekin, and Swanson, and Mr Hamilton), Pathology (Dr McCoy and Mr Schade), and Pediatrics (Dr Ragsdale), University of Michigan Medical School, Ann Arbor; and the Histocompatibility Laboratory (Ms Kapur), Veterans Administration Medical Center, Ann Arbor. Ms Kapur is currently with the Organ Transplantation Service, Walter Reed Army Medical Center, Washington, DC.

Arch Dermatol. 1986;122(6):650-654. doi:10.1001/archderm.1986.01660180056014

• The HLA type of patients with various kinds of immune reactions to bovine collagen implants were evaluated to determine a possible genetic basis for such responses. All patients suffering adverse clinical reactions to bovine collagen implants were lacking the HLA-DR4 antigen. All patients who received multiple bovine collagen injections without having adverse clinical reactions were lacking HLA-B5 and HLA-DR5 and had a significantly increased incidence of HLA-DR4. Combinations of histocompatibility antigens may influence immune response to bovine collagen implants.

(Arch Dermatol 1986;122:650-654)

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