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July 1986

Cutaneous Myxomas: A Major Component of the Complex of Myxomas, Spotty Pigmentation, and Endocrine Overactivity

Author Affiliations

From the Departments of Pathology (Dr Carney) and Dermatology (Dr Su), Mayo Clinic and Mayo Foundation, Rochester, Minn, and the Department of Pathology (Dr Headington), University of Michigan, Ann Arbor.

Arch Dermatol. 1986;122(7):790-798. doi:10.1001/archderm.1986.01660190068018

• Cutaneous myxoma(s) occurred in 22 (54%) of 41 patients with the complex of myxomas, spotty pigmentation, and endocrine overactivity. Of the 16 patients who had cardiac myxoma(s), the cutaneous tumor(s) was (were) detected in 13 (81%) of them prior to diagnosis of the cardiac neoplasm. Thus, the cutaneous tumor may herald a potentially fatal cardiac neoplasm (and other important conditions as well). Clinical features of the lesion were as follows: early appearance (mean age, 18 years); multicentricity (71% of patients); small size (usually less than 1 cm in diameter); widespread distribution but with predilection for certain sites (eyelids, ears, nipples); and tendency for recurrence. Pathologic features included the following: location in dermis, subcutis, or both; sharp circumscription (sometimes encapsulation); hypocellularity; abundant myxoid stroma; prominent capillaries; lobulation (larger lesions); and occasional presence of an epithelial component.

(Arch Dermatol 1986;122:790-798)

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