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August 1986

Squamous Cell Carcinoma in Lesions of Disseminated Superficial Actinic Porokeratosis: A Report of Two Cases

Author Affiliations

Department of Dermatology University of Texas Medical School at Houston Houston, TX 77030

Arch Dermatol. 1986;122(8):853-855. doi:10.1001/archderm.1986.01660200021004

To the Editor.—  Since the 1966 report by one of us (M.E.C.)1 of 12 patients with multiple superficial lesions of porokeratosis in sun-exposed areas and the proposed designation of disseminated superficial actinic porokeratosis (DSAP) as a variant of porokeratosis,2-4 the potential for a premalignant tendency has been debated. In 1982, Shrum et al5 described a patient who developed squamous cell carcinoma in a lesion of DSAP. We describe herein two other patients with squamous cell carcinomas occurring within DSAP lesions.

Report of Cases.—Case 1.—  A 47-year-old woman with a light complexion first presented in 1966. She had a twoyear history of the development of multiple lesions on exposed areas. Clinically, the lesions were a superficial type of porokeratosis and results of a biopsy showed a small, not very prominent, cornoid lamella consistent with DSAP.Over the years, the DSAP lesions increased in number; they

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