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August 1986

Selective Decrease of 15-Hydroxyeicosatetraenoic Acid (15-HETE) Formation in Uninvolved Psoriatic Dermis

Author Affiliations

From the Department of Dermatology, University of Michigan Medical School, Ann Arbor. Dr Kragballe is now with the Department of Dermatology, Marselisborg Hospital, University of Århus, Denmark.

Arch Dermatol. 1986;122(8):877-880. doi:10.1001/archderm.1986.01660200049012

• Epidermis of psoriatic skin lesions is characterized by elevated 5-lipoxygenase and 12-lipoxygenase products. 15-hydroxyeicosatetraenoic acid (15-HETE), the predominant lipoxygenase product in normal dermis, has the potential to inhibit 5-lipoxygenase and 12-lipoxygenase. The purpose of the present study was to determine the capacity of homogenized dermis from uninvolved psoriatic skin to form 15-HETE in vitro. Extracted lipids were separated by reversed-phase high-performance liquid chromatography. Each chromatographic peak was identified by its coelution with authentic standards, by ultraviolet spectrometry, and by radioimmunoassay. Dermis from uninvolved psoriatic skin generated on average 48% less 15-HETE than normal dermis (P <.01). In contrast, the formation of 12-hydroxyeicosatetraenoic acid was increased by 56% in psoriatic dermis (P <.01). Prostaglandin E2 formation was similar in normal and psoriatic dermis. Since 15-HETE can inhibit the synthesis of 5-lipoxygenase and 12-lipoxygenase products that possess inflammatory and proliferative capacities, a defective 15-HETE generation in dermis may be of importance for the development of psoriasis.

(Arch Dermatol 1986;122:877-880)