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August 1986

Reversible Hyperpigmentation of Skin and Nails With White Hair due to Vitamin B12 Deficiency

Author Affiliations

From the Division of Dermatology (Dr Noppakun) and the Division of Hematology (Dr Swasdikul), Department of Medicine, Chulalongkorn Hospital Medical School, Bangkok, Thailand.

Arch Dermatol. 1986;122(8):896-899. doi:10.1001/archderm.1986.01660200068018

• A case of reversible generalized hyperpigmentation of the skin and nails with reversible premature gray hair due to vitamin B12 deficiency is reported. The cause of the vitamin B12 deficiency in this patient was pernicious anemia. The pigmentation of his skin and hair returned to normal after treatment with intramuscular cyanocobalamin.

(Arch Dermatol 1986;122:896-899)

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