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November 1986

Coexistence of Hydroa Vacciniforme and Malignant Lymphoma

Author Affiliations

From the Department of Dermatology (Drs Oono, Arata, and Masuda) and Second Department of Pathology (Dr Ohtsuki), Kochi (Japan) Medical School.

Arch Dermatol. 1986;122(11):1306-1309. doi:10.1001/archderm.1986.01660230098020

• Ten years after the onset of hydroa vacciniforme (HV), a 16-year-old boy developed edema and red induration of the face, ears, and dorsa of the hands. Aggravation of cutaneous manifestations was associated with general malaise, headache, fever, lymphadenopathy, hepatosplenomegaly, and an increase of several serum enzymes. The vesicle was situated intraepidermally with thrombosis and hemorrhage underneath. This confirmed the diagnosis of HV. In addition, dense cell infiltrate was seen in deep dermis and subcutaneous tissue. Histologic and immunohistochemical studies of the dermal cell infiltrate and lymph node showed an infiltrate of helper T lymphocytes with an atypia and histiocytic cells (S100[—], α-subunit[+]). Hence, we concluded HV and malignant lymphoma coexisted in this patient.

(Arch Dermatol 1986;122:1306-1309)

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