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December 1986

The Sign of Leser-Trélat in a Young Man

Arch Dermatol. 1986;122(12):1356-1357. doi:10.1001/archderm.1986.01660240018004

To the Editor.—  The development of multiple seborrheic keratoses in a patient with an associated internal malignancy has been referred to as the sign of Leser-Trélat. This condition is almost always diagnosed in elderly people who have an underlying adenocarcinoma, usually of the gastrointestinal tract. We present the rare occurrence of multiple eruptive seborrheic keratoses in a 22-year-old man who had an intracranial tumor. The significance of this case is discussed herein with respect to the validity of the sign of Leser-Trélat.

Report of a Case.—  A 22-year-old man presented to the Letterman Army Medical Center, San Francisco, in August 1984, with persistent headaches, diplopia, and bilateral papilledema. Results of a computed tomographic scan revealed enlarged lateral and third ventricles, as well as an enlarged calcified pineal body. Results of a subsequent nuclear magnetic resonance study confirmed these findings and were suggestive of a germinoma. The α1-fetoprotein level was 22

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