To the Editor.—
Captopril is a potent angiotensinconverting enzyme inhibitor used to treat patients with hypertension. Adverse cutaneous reactions of diverse morphology are the most common side effects observed during captopril therapy.1-5 To our knowledge, there have been two previous case reports, only one in the English language, implicating captopril as a cause of a pemphigus-like eruption.6,7 We have observed a third patient with clinical and histologic features of pemphigus that can be attributed to the administration of captopril.
Report of a Case.—
A 72-year-old man received captopril therapy (25 mg four times a day) for essential hypertension. He had a long history of cardiac disease, for which he was receiving therapy with isosorbide dinitrate, digoxin, furosemide, and a potassium supplement; he was also using a Nitrodisk. Eleven months after starting the captopril therapy he developed an eruption on his forehead that slowly progressed to involve the upper
Ronald A. Katz, Antoinette F. Hood, Grant J. Anhalt. Pemphigus-like Eruption From Captopril. Arch Dermatol. 1987;123(1):20–21. doi:10.1001/archderm.1987.01660250024004