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January 1987

Pemphigus-like Eruption From Captopril

Author Affiliations

Department of Dermatology Washington Hospital Center 106 Irving St NW Washington, DC 20010; Baltimore

Arch Dermatol. 1987;123(1):20-21. doi:10.1001/archderm.1987.01660250024004

To the Editor.—  Captopril is a potent angiotensinconverting enzyme inhibitor used to treat patients with hypertension. Adverse cutaneous reactions of diverse morphology are the most common side effects observed during captopril therapy.1-5 To our knowledge, there have been two previous case reports, only one in the English language, implicating captopril as a cause of a pemphigus-like eruption.6,7 We have observed a third patient with clinical and histologic features of pemphigus that can be attributed to the administration of captopril.

Report of a Case.—  A 72-year-old man received captopril therapy (25 mg four times a day) for essential hypertension. He had a long history of cardiac disease, for which he was receiving therapy with isosorbide dinitrate, digoxin, furosemide, and a potassium supplement; he was also using a Nitrodisk. Eleven months after starting the captopril therapy he developed an eruption on his forehead that slowly progressed to involve the upper

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