[Skip to Content]
[Skip to Content Landing]
January 1987

Dysplastic Nevus in Histologic Contiguity With Acquired Nonfamilial Melanoma: Clinicopathologic Experience in a 100-Bed Hospital

Author Affiliations

From the Yale Melanoma Unit and the Departments of Pathology (Dr Duray) and Internal Medicine (Dr Ernstoff), Yale University School of Medicine, New Haven, Conn. Dr Ernstoff is now with the University of Pittsburgh School of Medicine.

Arch Dermatol. 1987;123(1):80-84. doi:10.1001/archderm.1987.01660250086025

• In the face of alarming rates of increase in melanoma worldwide, dysplastic nevi, especially any that are clinically changing in size, color, or borders, may be regarded as playing a potential role in the progression to a tumor stage. Dysplastic nevi are known to occur in multiples in family members of heritable malignant melanoma. Intraepidermal atypical melanocytes fulfilling the criteria of the dysplastic nevus were seen in histologic contiguity with superficial malignant nonfamilial melanomas in six of 13 patients. With one exception, all melanomas in this study that were associated with histologically contiguous dysplastic nevi were relatively thin, allowing identification of the melanoma at a potentially curable stage.

(Arch Dermatol 1987;123:80-84)