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January 1987

Mycosis Fungoides Associated With Dystrophic Xanthomatosis

Author Affiliations

From the Division of Dermatology, Department of Medicine (Drs McCadden and King), and the Department of Pathology (Dr Glick), Vanderbilt University Medical Center, Nashville, Tenn; and the Division of Dermatology, Department of Medicine, Veterans Administration Medical Center, Nashville, Tenn (Drs McCadden and King).

Arch Dermatol. 1987;123(1):91-94. doi:10.1001/archderm.1987.01660250097028

• A 59-year-old man with no evidence or history of hyperlipidemia had a dystrophic xanthoma, an accumulation of lipid-rich foam cells in an area of damaged or abnormal skin, that was associated with untreated mycosis fungoides (MF). The patient was subsequently treated with whole-body electron beam therapy. This association of MF and dystrophic xanthoma illustrates histiocyte and xanthoma cell interaction in MF, a cutaneous T-cell lymphoma. Xanthomas may be a cutaneous sign of an underlying lymphoproliferative or myeloproliferative disease in normolipemic patients.

(Arch Dermatol 1987;123:91-94)