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February 1987

Arachidonic Acid Metabolites in Cutaneous Carcinomas

Author Affiliations

The Middlesex Hospital Mortimer Street London W1N 8AA, England

Arch Dermatol. 1987;123(2):159. doi:10.1001/archderm.1987.01660260027002

To the Editor.—  We were interested in the findings of Vanderveen et al,1 who showed elevated levels of prostaglandins E2 and F (PGE2 and PGF) in cutaneous carcinomas, and even higher levels in those tumors exhibiting an aggressive growth pattern. However, we feel that the authors have not taken into sufficient account the possible contribution of endothelial cells to these eicosanoid levels and the interrelationship between the behavior of the tumors and the underlying blood vessels.The products of arachidonic acid metabolism in endothelial cells include PGI2, PGE2, and PGF.2 Data from isolated vessel segments and cultured endothelial cells suggest that the quantities of these prostaglandins synthesized depends on the site and size of the blood vessels.3 Thus, PGI2 is the major product from large blood vessels, whereas PGF and PGE2 appear to be the major products

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