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February 1987

Mast Cell Numbers in Diffuse Scleroderma

Author Affiliations

From the Department of Dermatology, Osaka (Japan) University School of Medicine. Dr Nishioka is now with Kitasato University School of Medicine, Kanagawa, Japan.

Arch Dermatol. 1987;123(2):205-208. doi:10.1001/archderm.1987.01660260075017

• Numbers of mast cells were quantitated in the lesions of diffuse scleroderma and morphea. Mast cells increased and then decreased in number in the papillary dermis of diffuse scleroderma. No significant change of mast cell numbers was noted in the reticular dermis. Mast cells increased in the papillary dermis with fine collagen bundles (grade 2 skin of scleroderma) and decreased in the papillary dermis with homogeneous collagen bundles (grade 3 skin of scleroderma). The total number of cells increased in the papillary dermis of grade 1 and 2 skin of scleroderma and decreased in the grade 3 skin of scleroderma. In morphea a reduced number of mast cells was noted in grade 3 lesions. It is suggested that mast cells play an important role in fibrotic process of scleroderma skin.

(Arch Dermatol 1987;123:205-208)

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