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February 1987

Scleredema and Paraproteinemia: Enhanced Collagen Production and Elevated Type I Procollagen Messenger RNA Level in Fibroblasts Grown From Cultures From the Fibrotic Skin of a Patient

Author Affiliations

From the Departments of Dermatology (Drs Oikarinen and Palatsi), Medical Biochemistry (Dr Ala-Kokko), and Anatomy (Dr Peltonen), and Collagen Research Unit, University of Oulu, Finland; and the Department of Medicine, UCLA School of Medicine, and the Division of Dermatology, Harbor-UCLA Medical Center, Torrance, Calif (Dr Uitto).

Arch Dermatol. 1987;123(2):226-229. doi:10.1001/archderm.1987.01660260096022

• An edematous rash developed on the abdominal skin of a 76-year-old woman who had had diabetes mellitus for ten years. Some months later, the affected skin became thickened and indurated. Histopathologic examination revealed marked dermal fibrosis with excessive deposition of collagen. The patient also had IgA (κ-type) paraproteinemia. Fibroblast cultures from the affected and unaffected skin were studied for collagen metabolism. Procollagen synthesis was elevated about sixfold on fibroblasts derived from the affected skin. A similar increase was detected in messenger RNA (mRNA) levels using a complementary DNA clone specific for human proα1(1) collagen mRNA. The elevated mRNA level could be the result of increased transcriptional activity of collagen genes or decreased degradation of collagen mRNAs. Our findings suggest that increased collagen deposition may account for the marked dermal fibrosis that we observed in this patient.

(Arch Dermatol 1987;123:226-229)

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