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March 1987

Human Papillomavirus Heterogeneity in 36 Renal Transplant Recipients

Author Affiliations

From the Departments of Dermatology (Drs Van der Leest and Bender) and Microbiology and Institute of Human Genetics (Ms Zachow and Drs Ostrow and Faras), University of Minnesota Medical School, Minneapolis; and Molecular Genetics Inc (Dr Pass), Minnetonka, Minn. Dr Van der Leest is now with the Permanente Medical Group, Fremont, Calif.

Arch Dermatol. 1987;123(3):354-357. doi:10.1001/archderm.1987.01660270092022

• Immunosuppressed patients such as renal transplant recipients are prone to increased incidence of wart disease. We examined 48 tissue specimens from 36 renal transplant recipients using human papillomaviruses (HPVs) 1, 2, 3, 4, 5, and 6 in filter hybridization under stringent conditions. The results showed that 90% of the samples contained HPV DNA. Of these 43 positive samples, we found HPV-1 in 2%, HPV-2 in 56%, HPV-3 in 19%, HPV-4 in 47%, HPV-5 in 9%, and HPV-6 in 5%. In several cases, more than one type of HPV DNA was observed. In a few of these cases, the clinical appearance of the lesions differed from what might have been expected, such as those lesions containing HPV-3— or HPV-5—related DNAs.

(Arch Dermatol 1987;123:354-357)

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