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March 1987

Human Papillomavirus Type 16 in Bowenoid Papulosis, Intraoral Papillomas, and Squamous Cell Carcinoma of the Tongue

Author Affiliations

From the Departments of Medicine, Division of Dermatology (Dr Lookingbill), Pathology (Drs Kreider and Olmstead), Microbiology (Drs Kreider and Howett), and Surgery (Dr Conner), Pennsylvania State University, College of Medicine, Hershey.

Arch Dermatol. 1987;123(3):363-368. doi:10.1001/archderm.1987.01660270101024

• A 33-year-old immunosuppressed man developed bowenoid papulosis on his genitalia, velvety papules and plaques in his mouth, and invasive squamous cell carcinoma of his tongue. All three lesions were positive for human papillomavirus type 16 (HPV-16). The case provides further circumstantial evidence for a role of HPV-16 in epithelial neoplasia. The possible roles of a second HPV infection and of immunosuppression are also discussed.

(Arch Dermatol 1987;123:363-368)