• A mother and daughter with lichen sclerosus et atrophicus (LSA) are described. Both had lesions restricted to their lower legs. Both patients were positive for HLA-B40, which has been associated with LSA. Sex steroid hormones showed no decrease in dihydrotestosterone, free testosterone, or androstenedione levels in the daughter as was demonstrated in a previous study of this disease, but did show some decrease in androstenedione in the mother. This article provides further evidence for a possible familial predisposition for LSA.
(Arch Dermatol 1987;123:485-488)
Shirer JA, Ray MC. Familial Occurrence of Lichen Sclerosus et AtrophicusCase Reports of a Mother and Daughter. Arch Dermatol. 1987;123(4):485–488. doi:10.1001/archderm.1987.01660280087030
Customize your JAMA Network experience by selecting one or more topics from the list below.