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June 1987

Epidermal Appendage Tumors in Xeroderma Pigmentosum

Author Affiliations

Institute of Oncology Hacettepe University Ankara, Turkey

Arch Dermatol. 1987;123(6):713-714. doi:10.1001/archderm.1987.01660300029007

To the Editor.—  Neoplastic changes seen in xeroderma pigmentosum (XP) are basal and squamous cell carcinomas, malignant melanomas, keratoacanthomas, angiomas, fibromas, and sarcomas.1 Xanthomas, neurofibromas,2 and true neuromas3 have also been reported in XP. To this list we add two epidermal appendage tumors, a pilomatricoma (Malherbe's calcifying epithelioma), and a sebaceous gland carcinoma.

Report of a Case.—  A 7-year-old boy was admitted to Hacettepe University Hospital, Ankara, Turkey, on Sept 29, 1970, due to dry, freckled, and scaly facial skin. This disorder, which had developed at 1.5 years of age, was related to sunlight exposure. Medical history revealed parental consanguinity and presence of the same disorder in two of five siblings. Physical signs, which included telangiectasia, small areas of hypopigmentation, and atrophy of facial skin, led to a clinical diagnosis of XP. There were no dysplastic nevi. The patient's neurologic examination results and mental status were normal.

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