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June 1987

Acute Graft-vs-Host Disease: Development Following Autologous and Syngeneic Bone Marrow Transplantation

Author Affiliations

From the Departments of Dermatology (Drs Hood, Black, and Farmer) and the Bone Marrow Transplantation Program of The Johns Hopkins Oncology Center (Drs Vogelsang and Santos), The Johns Hopkins University School of Medicine, Baltimore.

Arch Dermatol. 1987;123(6):745-750. doi:10.1001/archderm.1987.01660300067014

• Graft-vs-host disease (GVHD) is a frequent complication of allogeneic bone marrow transplantation but has been infrequently reported following autologous or syngeneic bone marrow transplantation. Ninety-six autologous and 19 syngeneic marrow transplants were performed at our institution between July 1977 and March 1984. We report acute cutaneous GVHD occurring in seven patients who received autologous marrow and two patients who received marrow from an identical twin. All nine patients had clinically detectable eruptions and had skin biopsy specimens with histologic changes of grade 2 acute GVHD. Although most cases were mild and self-limiting, four patients required systemic corticosteroids to treat their disease. Thus, acute cutaneous GVHD was seen in approximately 8% of patients receiving autologous or syngeneic bone marrow transplants at our institution.

(Arch Dermatol 1987;123:745-750)

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