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July 1987

Angiolymphoid Hyperplasia With Eosinophilia: Monoclonal Leukocyte Antibody Studies in Two Cases

Author Affiliations

Department of Dermatology Mayo Clinic and Mayo Foundation Rochester, MN 55905

Arch Dermatol. 1987;123(7):866-867. doi:10.1001/archderm.1987.01660310030007

To the Editor.—  Angiolymphoid hyperplasia with eosinophilia (ALHE) is a tumorlike vascular proliferation in the skin which presents as single or multiple, red-brown papules or nodules involving the head and neck region. It is characterized histopathologically by the following: (1) prominent vascular hyperplasia; (2) round, plump, "hobnailed" endothelial cells; (3) arteriovenous shunts and intravascular proliferation; and (4) a variable mixed-cell infiltrate dominated by lymphocytes and eosinophils.It is agreed that ALHE is a benign disease, but whether it is a primary proliferation of endothelial cells, a secondary reactive response to trauma, or a hyperestrogen state has not yet been determined.1 To shed more light on this issue, we performed monoclonal leukocyte antibody studies in two cases of ALHE seen at the Mayo Clinic, Rochester, Minn.

Report of Cases.—Case 1.—  A 53-year-old woman presented in 1982 with a history of itching nodules on the posterior aspects of the

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