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July 1987

Neurofibromatosis: The Importance of Localized or Otherwise Atypical Forms

Author Affiliations

NF Program Baylor College of Medicine Houston, TX 77030

Arch Dermatol. 1987;123(7):882-883. doi:10.1001/archderm.1987.01660310050011

When we ask "What is neurofibromatosis (NF)?" and try to answer this question in depth, we quickly realize that our answers are incomplete in many ways. Most importantly, NF is no longer one single disease: rather it is a conglomeration of disorders with overlapping features and no one feature common to all the disorders. My own attempts to deal with this heterogeneity1,2 have led to the schema referred to in the article by Roth et al3 in this issue of the Archives. The key to this approach is my conviction that, anyone who has broad experience in the systematic evaluation of patients with or at-risk for NF will derive the same set of NF categories or NF types. Other, less comprehensive schemes usually result if the investigator has a more narrowly focused approach to NF or if consensus of multiple investigators is required. For example, a February 1986

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