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July 1987

Skin Models: Models to Study Function and Disease of the Skin,

Arch Dermatol. 1987;123(7):957. doi:10.1001/archderm.1987.01660310127028

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This book is an interesting compendium of research techniques for modeling of skin physiology and pathology. It is divided into three sections entitled "In Vivo Models," "In Vitro Models," and "Mathematical and Physical Models." There are a total of 47 articles presented in a book of 437 pages; thus, most presentations are brief. Articles vary from short discussions to detailed "how-to" descriptions and are well referenced. The modeling systems described are quite varied, and many of them are likely to be new to other investigators. However, this book is not a general review of techniques useful in research in dermatology. There is a strong concentration on methods of relevance to toxicology and pharmacology. However, there is little mention of in vitro culture techniques for keratinocytes or melanocytes and, with the exception of a short section on dinitrobenzene sensitization in humans (which, given the mutagenicity of dinitrobenzene, is not recommended), there

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