To the Editor.—
Since elastosis perforans serpiginosa (EPS) was first described, it has been suggested that it is a phenomenon caused by a variety of abnormal elastic fibers. At least three etiologic types are now considered to be involved, ie, the idiopathic, the reactive, and the penicillamine-induced.1-3 Previous ultrastructural investigations showed that the abnormal elastic fibers in the idiopathic type differ in structure from those of the penicillamine-induced type.1,3-6 The reactive type, which is associated with different congenital disorders, mostly of the connective tissue, such as Down's syndrome, osteogenesis imperfecta, Marfan's syndrome, pseudoxanthoma elasticum, and Ehlers-Danlos syndrome (EDS), has not been as extensively studied.7 It remains to be demonstrated whether it is a unique structural form of EPS.We performed an ultrastructural study in two patients with the reactive type of EPS.
Report of Cases.—Case 1.—
A 15-year-old girl presented with osteogenesis imperfecta, type Ia,
Bergman R, Friedman-Birnbaum R, Ludatscher R, Lichtig C. An Ultrastructural Study of the Reactive Type of Elastosis Perforans Serpiginosa. Arch Dermatol. 1987;123(9):1127–1129. doi:10.1001/archderm.1987.01660330034007
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.