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September 1987

Association of Progressive Systemic Scleroderma to Several HLA-B and HLA-DR Alleles

Author Affiliations

From the Dermatological Clinic and Polyclinic of the Rheinische Friedrich-Wilhelms University, Bonn, West Germany (Dr Luderschmidt); the Laboratory for Immunogenetics of the Polyclinic of the Ludwig-Maximilian University (Drs Scholz, Mehlhaff, and Albert), and the Pneumonological Department of the Medical Clinic I Klinikum Grosshadern of the Ludwig-Maximilian University (Dr König), Munich.

Arch Dermatol. 1987;123(9):1188-1191. doi:10.1001/archderm.1987.01660330099019

• The HLA-A, B, C, and DR loci of 136 patients with progressive systemic scleroderma have been determined. The patients were classified according to the extent of their skin affection and into groups with or without immunologic and inflammatory signs of the disease. The antigens of the A locus did not show any significant deviations in frequency of occurrence. An increase of HLA-B8 and HLA-DR3 was only proved in the male patient group. Furthermore, in the HLA-DR gene locus, an increase in frequency of HLA-DR1, 2, 3, and 5 could be found. However, in the total set of patients, only the correlation of HLA-DR5 with progressive systemic scleroderma reached significance. Patients suffering from the CREST (calcinosis, Raynaud's phenomenon, esophagus, sclerodactyly, and telangiectasia) syndrome showed an increase of HLA-DR1. Patients with inflammatory signs of the scleroderma showed an accumulation of HLA-DR2. Several HLA-linked genes control the susceptibility to scleroderma.

(Arch Dermatol 1987;123:1188-1191)

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