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September 1987

Perforating Granuloma Annulare in a Patient With Acquired Immunodeficiency Syndrome: Immunohistologic Evaluation of the Cellular Infiltrate

Author Affiliations

From the Departments of Dermatology (Drs Huerter and Bergfeld) and Pathology (Drs Bass, Bergfeld, and Tubbs), Cleveland Clinic Foundation.

Arch Dermatol. 1987;123(9):1217-1220. doi:10.1001/archderm.1987.01660330128025

• The inflammatory infiltrate found in the lesions of perforating granuloma annulare in a patient with acquired immunodeficiency syndrome was analyzed. Double labeling with fluorescent antibody tags fluorescein isothiocyanate—Leu 4 (peripheral T cells) and phycoerythrin-Leu 2a (cytotoxic/suppressor) revealed the infiltrate to consist predominantly of cytotoxic/suppressor T cells. This finding is a reflection of the patient's altered immune status and calls into question the role of specific T-cell subsets in the pathogenesis of granuloma annulare.

(Arch Dermatol 1987;123:1217-1220)

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