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October 1987

Cross-reference of Same Patients in Different Studies

Author Affiliations

Department of Dermatology Oulu University Central Hospital SF-90220 Oulu, Finland

Arch Dermatol. 1987;123(10):1268. doi:10.1001/archderm.1987.01660340028007

To the Editor.—  Recently, an article entitled "Scleredema and paraproteinemia: Enhanced collagen production and elevated type I procollagen messenger RNA level in fibroblasts grown from cultures from the fibrotic skin of a patient" by Oikarinen et al was published in the Archives.1 The same patient that was in this study was also included in another study by Ohta et al2 that was published in the Journal of the American Academy of Dermatology this January. In the last-mentioned article, four patients with scleredemalike skin changes and paraproteinemia were studied. Even though the same patient was included in both studies, the approach and methods of these studies were totally different. In the article by Oikarinen et al, the most important finding was that collagen synthesis and collagen messenger RNA were markedly elevated in the cell cultures from the fibrotic skin. However, the role of serum factors (ie, paraproteins) was not

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