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October 1987

True Histiocytic Lymphoma Associated With Dermatomyositis

Author Affiliations

Department of Dermatology Osaka University School of Medicine Osaka 553, Japan; Department of Pathology Osaka University School of Medicine

Arch Dermatol. 1987;123(10):1272-1274. doi:10.1001/archderm.1987.01660340032011

To the Editor.—  Dermatomyositis (DM) and polymyositis (PM) are connective tissue diseases that are frequently associated with cancer.1,2 Association of DM and PM with malignant lymphomas in general1,2 and true histiocytic lymphoma, in particular, has not been established.3-5 In this report, we describe a case of true histiocytic lymphoma associated with dermatomyositis.

Report of a Case.—  A 65-year-old man had noticed skin tumors associated with fever since January 1981. In March 1982, he presented with several brownish-red skin tumors with firm, well-circumscribed borders less than 3 cm in diameter on his extremities and trunk. The axillary and inguinal lymph nodes were palpable. Slight hepatosplenomegaly was found by abdominal computed tomography. Abnormal laboratory findings included the following: lactate dehydrogenase, 425 U/L (normal, <249 U/L); creatine phosphokinase, 397 U/L (normal, <130 U/L); and aldolase, 9 U/L (normal, <5 U/L). Chest roentgenogram showed changes consistent with a previously diagnosed case