[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
October 1987

Perineural Invasion Associated With Recurrent Sporadic Multiple Self-healing Squamous Carcinomas

Author Affiliations

Baylor Medical Plaza 3600 Gaston Ave Suite 1154 Dallas, TX 75246; Baylor University Medical Center; Beth Israel Hospital Boston

Arch Dermatol. 1987;123(10):1275-1276. doi:10.1001/archderm.1987.01660340035013

To the Editor.—  Ferguson Smith1 did not realize that he had discovered an autosomal-dominant trait when he reported a single case of multiple self-healing squamous carcinomas (MSHSC) in 1934.2 It is now recognized that both familial and sporadic types of MSHSC exist. Both entities are now included in the designation of multiple Ferguson-Smith keratoacanthomas. The MSHSC are occasionally known for an extremely mutilating course and fatal outcome. The patient initially described by Ferguson Smith was again cited 14 years later for extensive nasal destruction that required a prosthesis.3 Charteris4 described a patient with MSHSC who died as a result of an extensive recurrent anal lesion. We report a patient with sporadic MSHSC who experienced extensive recurrent perineural invasion of the right supratrochlear nerve. This observation suggests that perineural invasion by keratoacanthoma should not be regarded as an entirely benign condition.

Report of a Case.—  A 44-year-old