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October 1987

Dysplastic Nevus Syndrome

Author Affiliations

Department of Dermatology University of Munich 8000 Munich 2, West Germany

Arch Dermatol. 1987;123(10):1280. doi:10.1001/archderm.1987.01660340040017

To the Editor.—  The dysplastic nevus syndrome (DNS) was originally described by Clark and coworkers1 in 1978 as the heritable association of atypical nevi and malignant melanoma (MM). Later, a nonfamilial form of this syndrome was described,2 and it has been claimed that more than 50% of all patients with MM had clinical or histologic evidence of DNS,3 and that the occurrence of a solitary dysplastic nevus in the general population may be as high as 2% to 5%.4 The dysplastic nevus is generally regarded as an important precursor of MM.5 However, the significance of DNS and of solitary dysplastic nevi with regard to the development of MM is not certain.Our clinical impression was that the frequencies of DNS and solitary dysplastic nevi in patients with MM were far lower than have been reported. We, therefore, reviewed 211 cases of histologically confirmed MM. Total

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