To the Editor.—
In this study, the in vitro release of minoxidil from creams and lotions (which appear in the literature for the treatment of several forms of alopecia) was studied. The release of the drug from the creams was found to be 50% less than its release from the lotions. The release profile of minoxidil was similar for all the lotions that were examined. There was no significant difference between the release of the drug from the creams. A formulation of minoxidil prepared with propylene glycol:water:ethanol (15:15:70) is suggested for topical use, especially when the drug is available from tablets only.Topically applied minoxidil has been used recently for the treatment of alopecia areata and malepattern alopecia.1-3 Several formulations of minoxidil have been suggested for topical use that are prepared today by the pharmacist. These pharmaceutical preparations have not been tested comparatively with respect to the drug being
Paraskevas D, Rekkas D, Choulis N, Hatzis J, Stratigos J. In Vitro Release of Minoxidil From Topical Formulations. Arch Dermatol. 1987;123(11):1433–1435. doi:10.1001/archderm.1987.01660350027007
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