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November 1987

Immediate Hypersensitivity Reaction to Amphibian Serum Manifesting as Hand Eczema

Author Affiliations

Los Alamos Medical Center Los Alamos, NM 87544

Arch Dermatol. 1987;123(11):1436-1437. doi:10.1001/archderm.1987.01660350030009

To the Editor.—  Warts are not acquired from toads, but contact hypersensitivity can be. We report a case of an immediate hypersensitivity reaction to amphibian serum in a biochemistry laboratory worker that manifested as hand eczema and rhinoconjunctivitis.

Report of a Case.—  A 26-year-old woman presented with a three-month history of an eczematous reaction on the tips of the left thumb as well as index and long fingers. In approximately monthly cycles, the skin became red, scaly, and insensitive to cold and heat, and then would heal in four to seven days. Her job in a biochemistry laboratory, which she had begun shortly before the onset of this reaction, involved periodic contact with toads (Bufo marinis) and frogs (Rana catesbeiana). She killed the amphibians and handled serum and peritoneal fluid. Wearing latex gloves did not prevent the eruption. Initially she felt that the eruption did not correlate with the handling

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