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November 1987

The Effect of 13-cis-Retinoic Acid on Sebaceous Glands

Author Affiliations

From the Marshall Research Dermatology Research Laboratories, Department of Dermatology, University of Iowa College of Medicine, Iowa City.

Arch Dermatol. 1987;123(11):1538a-1541. doi:10.1001/archderm.1987.01660350142031

• The drug, 13-cis-retinoic acid, which has been demonstrated to have a marked effect on nodulocystic acne, probably has several mechanisms of action. This article summarizes the effects on the sebaceous glands, and the accompanying changes in cutaneous lipids that result from 13-cis-retinoic acid therapy. These changes in lipid composition support the concept that linoleate may be of importance in the pathogenesis of acne.

(Arch Dermatol 1987;123:1538a-1541)

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