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December 1987

Acquired Nonfamilial Melanoma: An Inappropriate Conclusion

Author Affiliations

Section of Dermatology Department of Internal Medicine University of Nebraska Medical Center 42nd Street and Dewey Avenue Omaha, NE 68105-1065; Department of Preventive Medicine Hereditary Cancer Institute and Consultative Center Creighton University Medical School Omaha, NE 68178

Arch Dermatol. 1987;123(12):1595-1596. doi:10.1001/archderm.1987.01660360023002

To the Editor.—  Duray and Ernstoff1 described 14 patients (probands) with acquired nonfamilial melanoma in which seven patients had histologically dysplastic nevi associated with primary cutaneous malignant melanoma. In defining their methodology, they made several statements that are crucial to understanding their conclusion. They stated that (1) "Our study was conducted primarily as a pathologic and medical chart review, with aid from the attending clinicians, and not as a detailed interview with multiple family members, yielding detailed pedigree studies"; (2) "We reviewed all histologic slides, pathologic reports, medical records (with the aid of the tumor registrar), and further information from the clinical attending physicians"; and (3) "All patients had no family histories for melanoma (back two generations) and thus were considered to have nonfamilial melanoma."The authors did not detail the depth of genetic verification of informative data on the pedigrees. It must be assumed that the information was

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