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December 1987

Acquired Nonfamilial Melanoma: An Inappropriate Conclusion-Reply

Author Affiliations

Department of Pathology Fox Chase Cancer Center 7701 Burholme Ave Philadelphia, PA 19111; Department of Medical Oncology Pittsburgh Cancer Institute University of Pittsburgh Pittsburgh, PA 15261

Arch Dermatol. 1987;123(12):1596-1597. doi:10.1001/archderm.1987.01660360024003

In Reply.—  We thank Fusaro and Lynch for their comments and their interest. We are gratified that the concept of the dysplastic nevus is being currently and actively debated. This is an important concept and, in the face of rising melanoma incidence, we are most appreciative of this exchange. Fusaro and Lynch correctly define and elucidate methods involved in pedigree analysis, and they are absolutely correct in stating criteria and methods for defining genetic syndromes within a detailed pedigree analysis. We thank them for sharing with us this correct method. It is true that we did not do a detailed pedigree analysis with detailed dermatologic examination of the multiple family members, but the study was not intended to do this, as we had stated in the article. The study was, as stated, a clinical pathologic review to ascertain the presence, if any, of dysplastic nevus elements histopathologically in skin surrounding the melanoma.

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