• We observed three children with a clinically similar presentation of erythematous nodules that expanded centrifugally leaving lipoatrophy. Areas of lipoatrophy coalesced, resulting in clinical pictures similar to partial or total lipodystrophy. Histologic study revealed a lobular panniculitis with a mixed infiltrate of lymphocytes and mononuclear phagocytes. Of these three children, one had insulin-dependent diabetes mellitus and Hashimoto's thyroiditis, one developed juvenile rheumatoid arthritis, and the third developed insulin-dependent diabetes mellitus, suggesting that the pathogenic mechanism may be an expression of autoimmunity.
(Arch Dermatol 1987;123:1662-1666)
Billings JK, Milgraum SS, Gupta AK, Headington JT, Rasmussen JE. Lipoatrophic Panniculitis: A Possible Autoimmune Inflammatory Disease of FatReport of Three Cases. Arch Dermatol. 1987;123(12):1662–1666. doi:10.1001/archderm.1987.01660360090018