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December 1987

Lipoatrophic Panniculitis: A Possible Autoimmune Inflammatory Disease of Fat: Report of Three Cases

Author Affiliations

From the Departments of Dermatology (Drs Billings, Milgraum, Gupta, Headington, and Rasmussen), Pathology (Dr Headington), and Pediatrics (Dr Rasmussen), University of Michigan Medical Center, Ann Arbor.

Arch Dermatol. 1987;123(12):1662-1666. doi:10.1001/archderm.1987.01660360090018

• We observed three children with a clinically similar presentation of erythematous nodules that expanded centrifugally leaving lipoatrophy. Areas of lipoatrophy coalesced, resulting in clinical pictures similar to partial or total lipodystrophy. Histologic study revealed a lobular panniculitis with a mixed infiltrate of lymphocytes and mononuclear phagocytes. Of these three children, one had insulin-dependent diabetes mellitus and Hashimoto's thyroiditis, one developed juvenile rheumatoid arthritis, and the third developed insulin-dependent diabetes mellitus, suggesting that the pathogenic mechanism may be an expression of autoimmunity.

(Arch Dermatol 1987;123:1662-1666)

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