Lupus erythematosus and Sjögren's syndrome have long been characterized as autoimmune diseases. However, the meaning behind the word autoimmune was and is often vague. Does "autoimmune" in the case of lupus erythematosus and Sjögren's syndrome imply autoantibody-mediated? If so, which autoantibodies are important? At this time, the pathogeneses of lupus erythematosus and Sjögren's syndrome have not been elucidated and it is not possible to answer these questions. Nevertheless, there is, at least in lupus erythematosus, a reasonably large body of experimental evidence supporting the possibility that autoantibody production is the primary abnormality.1 In New Zealand black/New Zealand white mice, a strain that spontaneously develops lupus erythematosus with glomerulonephritis, autoantibodies are the first observable abnormality. Detectable levels of antibodies to DNA precede the first signs of renal disease by a few weeks.2 Further, in many murine models of lupus erythematosus, the addition of a gene called xid results in
Lee LA. Anti-Ro (SSA) and Anti-La (SSB) Antibodies in Lupus Erythematosus and in Sjögren's Syndrome. Arch Dermatol. 1988;124(1):61–62. doi:10.1001/archderm.1988.01670010025016
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