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February 1988

Topical Fibronectin Therapy for Treatment of a Patient With Chronic Stasis Ulcers

Arch Dermatol. 1988;124(2):175-177. doi:10.1001/archderm.1988.01670020007002

To the Editor.—  Fibronectin (FN) is a glycoprotein that functions as a biological adhesive and mediates bonding between a variety of cell types and their extracellular matrices.1 Recent studies have shown that topical application of FN eyedrops is an effective therapeutic approach for resolving nonhealing ulcers of the corneal epithelium after herpetic keratitis2 and keratoconjunctivitis sicca.3Unlike the basal keratinocytes of unwounded skin that are attached to a basement membrane containing laminin and type IV collagen,4 keratinocytes that reepithelialize a wound bed move over/through an FN-rich matrix5,6 that lacks laminin and type IV collagen.7 Fibronectin promotes keratinocyte adhesion, motility, and phagocytosis.8-10 Also, a transient activation of keratinocyte adhesion to FN was observed during repair of full-thickness wounds in an animal model.11 Moreover, activation of keratinocyte adhesion has been found to be selective for FN relative to other matrix components, including collagen type I