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March 1988

Abnormal DNA Ploidy in Cells of the Epidermis in a Case of Porokeratosis

Arch Dermatol. 1988;124(3):331-332. doi:10.1001/archderm.1988.01670030019012

To the Editor.—  Recent clinical observations have revealed malignant epithelial tumors occasionally developing on the lesions of porokeratosis.1 A localized clone of abnormal epidermis has been presumed to be the most likely explanation for the skin lesion and the development of malignant tumors of porokeratosis, on the basis of histologic studies.2We examined a patient with porokeratosis of Mibelli in whom no malignant tumors had developed. Herein we describe the clinical and pathologic features of this case, and report the results of our DNA-microfluorometric studies, which suggest the existence of abnormal clones in the epidermis of this skin condition.

Report of a Case and Microfluorometric Studies.—  A 54-year-old woman visited us with recurrent small keratotic plaques on the abraded area of her left hand. She had been diagnosed as having porokeratosis of Mibelli on her elbow and on the dorsal side of her left hand, and had been

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