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March 1988

Cutaneous-Type Adult T-Cell Leukemia/Lymphoma: A Unique Clinical Feature With Monoclonal T-Cell Proliferation Detected by Southern Blot Analysis

Author Affiliations

From the Department of Dermatology, Faculty of Medicine, Kyoto (Japan) University.

Arch Dermatol. 1988;124(3):399-404. doi:10.1001/archderm.1988.01670030065024

• A 60-year-old woman suffered from multiple subcutaneous nodules with a self-limited clinical course. High titer of the antibody against the adult T-cell leukemia/ lymphoma (ATL)-associated cell antigen was detected and atypical lymphocytes were present in less than 1% of the peripheral leukocytes. Tumor cells were identified by the molecular biology technique Southern blot analysis, which showed monoclonal cell expansion of the helper/ inducer T cells integrated with human T-cell lymphotropic virus type I/adult T-cell leukemia virus. This patient was diagnosed as having the cutaneous type of smoldering ATL in a very early stage. In this case, only gene analysis of the skin lesion could facilitate making an early differential diagnosis of ATL from other lymphoproliferative diseases, including nonviral cutaneous T-cell lymphoma and benign lymphoid hyperplasia.

(Arch Dermatol 1988;124:399-404)

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