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March 1988

Ki-1+ Cutaneous Lymphoma: Gene Rearrangement Analysis of Tumor Cells in Tissue and Short-term Culture of a Patient

Author Affiliations

From the Department of Dermatology, Hamamatsu (Japan) University School of Medicine (Drs Sugimoto, Nakayama, Iwatsuki, Takigawa, and Yamada); the Department of Dermatology, Hamamatsu (Japan) Red Cross Hospital (Dr Tokura); the Department of Dermatology, Shizuoka (Japan) General Hospital (Dr Yamauchi); and the Chest Disease Research Institute, Kyoto (Japan) University (Dr Maeda).

Arch Dermatol. 1988;124(3):405-408. doi:10.1001/archderm.1988.01670030071025

• Cutaneous malignant lymphomas developed in an 80-year-old man without any evidence of leukemic disseminations of lymphoma cells. Immunohistologic staining showed the expression of Leu-3a, Leu-4, Ki-1, Tac, and HLA-DR antigens on tumor cells in tissue and large lymphoid cells in long-term, interleukin 2-containing culture of tumor explants. DNA samples extracted from the skin tumors and cultured lymphoid cells showed a clonal rearrangement of T-cell receptor (TCR) gene Cβ1 with the molecular size of 9 kilobases. These findings suggested the T-cell origin of Ki-1+ cutaneous lymphoma cells and the occurrence of a clonal proliferation of tumor cells in culture.

(Arch Dermatol 1988;124:405-408)

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