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April 1988

Basal Cell Carcinoma of the Skin Responding Completely to Chemotherapy

Author Affiliations

Queensland Radium Institute Royal Brisbane Hospital Brisbane, Queensland 4029, Australia

Arch Dermatol. 1988;124(4):494. doi:10.1001/archderm.1988.01670040014009

To the Editor.—  We describe a patient who had a very large basal cell carcinoma of the skin that had a biopsy-proved complete response to chemotherapy.

Report of a Case.—  A 78-year-old man presented with a 6 × 6 × 2-cm exophytic tumor over the left scapula, a 4-cm exophytic tumor over the central back, and a left hilar mass. A biopsy specimen of the two skin lesions revealed basal cell carcinoma. A biopsy specimen of the lung tumor revealed small cell carcinoma of the bronchus.He was treated for the lung carcinoma with an alternating combination chemotherapy as follows: cisplatin, 80 mg/m2 (day 1); etoposide, 60 mg/m2 (days 1 to 3); and vincristine sulfate, 1.4 mg/m2 (day 22), doxorubicin, 50 mg/m2 (day 22), and cyclophosphamide, 750 mg/m2 (day 22).Following the first cycle of cisplatin-etoposide therapy, there was rapid reduction in the size of

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