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April 1988

Bullous Eruption in a Woman With Lupus Erythematosus

Author Affiliations

University of Pennsylvania, Philadelphia

Arch Dermatol. 1988;124(4):571-572. doi:10.1001/archderm.1988.01670040073027

REPORT OF A CASE  The patient, a 26-year-old woman, presented with a six-year history of systemic lupus erythematosus (SLE), which had been diagnosed in 1979. The diagnosis of SLE was made at the time of splenectomy for idiopathic thrombocytopenia purpura associated with antiplatelet antibodies. The patient also had leukopenia, anemia, a malar skin rash, arthralgias, cicatricial alopecia, photosensitivity, and positive serologic findings, including positive antinuclear antibody and anti-DNA tests. For the past five years, the patient's SLE was controlled with hydroxychloroquine sulfate (Plaquenil) and prednisone; azathioprine (Imuran) was added as a steroid sparing agent during the past three years. Her medical history was otherwise unremarkable except for minimal chronic active hepatitis seen on a liver biopsy performed at the time of splenectomy.In February 1985, the patient was doing well on a regimen of 20 mg of prednisone, 100 mg of azathioprine, and 300 mg of hydroxychloroquine sulfate per day.