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May 1988

Isolation of Adenovirus From a Granuloma Annulare-like Lesion in the Acquired Immunodeficiency Syndrome-Related Complex

Arch Dermatol. 1988;124(5):654-655. doi:10.1001/archderm.1988.01670050012006

To the Editor.—  Unusual skin lesions, many of them due to viral infections, have been reported with increasing frequency in association with the acquired immunodeficiency syndrome (AIDS). An unusual granuloma annulare (GA)-like eruption of unknown etiology has been reported in three patients with AIDS.1,2 We present a patient with the AIDS-related complex (ARC) with a widespread GA-like skin eruption. Type 1 adenovirus was isolated from lesional skin in viral culture.

Report of a Case.—  A 27-year-old man with ARC was admitted for evaluation of paraparesis, dementia, and a progressive skin eruption of one-year duration. Examination revealed multiple erythematous papules and small nodules, which coalesced into plaques, predominantly on the extensor surfaces of his elbows, hands, and knees (Fig 1). There were a few scattered papules on the trunk. The papules had exaggerated skin markings, and they were often adjacent to white atrophic areas. There was no scaling or follicular

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